酷游ku111备用线路

酷游ku111备用线路:王欣之

发布者:花文婷发布时间:2022-09-27浏览次数:11


职称:  副教授    E-mail:xinzhiwang@njucm.edu.cn     主要研究方向:海洋药物(中药)质量标准、海洋来源天然产物抗肿瘤活性评价及机制研究


个人简介

       王欣之,副教授,硕士生导师。博士毕业于中国药科大学天然药物化学专业,美国加州大学伯克利分校劳伦伯克利国家实验室访问学者。目前任职于江苏省海洋药用生物资源研究与开发重点实验室。主要从事海洋药物(中药)质量标准、海洋来源天然产物抗肿瘤活性评价及机制研究。先后主持国家自然科学基金2项,江苏省自然科学基金2项,江苏省教育厅自然科学重大项目1项。参与国家海洋公益性行业专项2项,北海市十三五海洋经济创新发展示范市项目、江苏省海洋科技创新项目各1项。近年来,以第一或通讯作者在Redox Biology, 海洋学报(英文版)等SCI期刊上发表与研究领域相关的论文30余篇。现任江苏省药学会海洋药物专业委员会委员。


承担的主要科研项目

1. 国家自然科学基金面上项目,32074067,基于SUMO化修饰调控的中药石蝉草裂木脂素抗KRAS突变型肿瘤的作用机制研究,2021/01-2024/12,主持,55万,在研;

2. 江苏省高校自然科学重大项目,19KJA310006,菊芋倍半萜内酯抗白血病干细胞的机制及构效关系研究,时间: 2019/09-2022/09,主持,30万,在研;

3. 江苏省自然科学基金面上项目,BK20181419,Heliangolides型倍半萜内酯选择性抗白血病干细胞的机制及构效关系研究,2018/07-2022/07,主持,10万,在研;

4. 国家自然科学基金青年项目,81402812,基于分子对接技术的天然裂木脂素Peperomin E抗肿瘤靶标的寻找及结构优化研究,2015/01-2017/12,主持,23万,结题;

5. 江苏省自然科学基金青年项目,BK20130954,天然产物Peperomin E诱导胃癌细胞凋亡的机制和结构修饰研究,2013/06-2016/06,20万元,主持,结题。


代表性论文

1. Xin-zhi Wang, Yin Feng, Ye-fan Han, Yong Bian, Jie Liang, Hong-mei Wen, Hao Wu, Budlein A methylacrylate demonstrates potent activity against triple-negative breast cancer by targeting IκBα kinase and exportin-1. Toxicology and Applied Pharmacology. 408(2020):115263.

2. Xin-zhi Wang, Ming Gao, Jiyun Zhang, Ying Ma, Wenshu Qu, Jingyu Liang, Hao Wu, Hong-mei Wen. Peperomin E and its orally bioavailable analog induce oxidative stress-mediated apoptosis of human acute myeloid leukemia stem cells via targeting thioredoxin reductase. Redox Biology. 24(2019):101153.

3. Xin-zhi Wang, Hao Wu, Yin Cheng, Hongmei Wen. Multi-year assessment of paralytic shellfish toxins in hard clam species along the coastline of Jiangsu Province, China. Acta Oceanologica Sinica. 38(2019), 1-10.

4. Xin-zhi Wang*, Hong-mei Wen, Chuan Chai, Wen-ying Zhang, Ming Gao, Rui Liu, Hao Wu, Jiang-yu Liang. Determination of a natural DNMT1 inhibitor, Peperomin E, in rat plasma by UFLC-MS/MS and method application in a pharmacokinetic study. Biomedical Chromatography, 31 (2017), 3930-3937.

5. Ming Gao, Xinzhi Wang*, Yeting Shu, Jie Liang, Liang Chen, Rui Liu, Jing-yu Liang, and Hong-mei Wen. Peperomin E and its synthetic amino derivatives: potent agents against leukemia stem cells. RSC Advances, 7(2017): 52200-52209.

6. Xin-zhi Wang, Ying Cheng, Kui-long Wang, Rui Liu, Xiao-lin Yang, Hong-mei Wen, Chuan Chai, Jing-yu Liang, Hao Wu*. Peperomin E reactivates silenced tumor suppressor genes in lung cancer cells via inhibition of DNA methyltransferase. Cancer Science, 107 (2016) 1506-1519.

7. Xin-zhi Wang*, Ying Cheng, Hao Wu, Na Li, Rui Liu, Xiao-lin Yang, Yun-ying Qiu, Hong-mei Wen, and Jing-yu Liang. The natural secolignan peperomin E induces apoptosis of human gastric carcinoma cells via the mitochondrial and PI3K/Akt signaling pathways in vitro and in vivo, Phytomedicine, 23(2016) 818-827.

8. Xin-zhi Wang, Ying Cheng, Na Li, Hong-mei Wen, Rui Liu, Chen-xiao Shan, Chuan Chai, and Hao Wu*. Occurrence and seasonal variations of lipophilic marine toxins in commercial clam species along the coast of Jiangsu, China. Toxins, 8 (2016): 8-14.

9. Xin-zhi Wang, Jing-yu Liang, Hong-mei Wen*, Chen-xiao Shan, Rui Liu, Simultaneous determination of five bioactive secolignans in rat plasma by LC–MS/MS for pharmacokinetic studies following oral administration of Peperomia dindygulensis Miq. extract, Journal of Chromatography B, 9449(2014) 82-89.

10. Xin-zhi Wang, Jing-yu Liang, Hong-mei Wen*, Chen-xiao Shan, Rui Liu, Qualitative and quantitative analyses of bioactive secolignans from folk medicinal plant Peperomia dindygulensis  Miq. using UHPLC-UV/Q-TOF-MS, Journal of Pharmaceutical and Biomedical Analysis, 94(2014) 1-11.

 




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